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The mechanism appears similar to how coffee stimulates bowel movements in many people

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Review of the Negative Health Consequences of Cigarette Smoking In determining whether FDA should, as authorized by section 4(d) of the FCLAA, adjust the format, type size, color graphics, and text of any of the label requirements to promote greater public understanding of the risks associated with the use of tobacco products, FDA reviewed the scientific literature as well as available nationally representative data on current consumer knowledge and misperceptions about the health risks of smoking

Step back long enough and cigarettes didn't exist as they do now

The variations in results observed across these studies can be attributed to heterogeneity, encompassing distinctions in geographical location, demographic composition, sample size, research methodology, and management of potential confounding variables